Early RRT is Associated With a Decreased Risk of All-Cause Mortality


 


Review/ Nephrology 22 (2017) 7–18

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Initiation time of renal replacement therapy on patients with acute kidney injury: A systematic review and meta-analysis of 8179 participants

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·        Renal replacement therapy (RRT) has long been used as a supportive treatment for AKI and plays an important role in the recovery of kidney function.

 

·         We conducted a systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

 

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» This systematic review and meta-analysis showed a 25% reduction in all-cause mortality in patients assigned to early RRT compared with those receiving late RRT.

 

» Additionally, patients assigned to early RRT had a lower duration of hospitalization and mechanical ventilation.

 

» Our systematic review suggests that early RRT can reduce the duration of mechanical ventilation and hospitalization in patients assigned to early RRT, which means patients may recover with less medical expenditures.

 

 

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∎∎∎ Patients with AKI are at high risk of mortality. Our systematic review and meta-analysis suggests that early RRT is associated with a decreased risk of all-cause mortality compared with late RRT in patients with AKI. Additionally, we show that early RRT can benefit patients with AKI in renal recovery, duration of mechanical ventilation and hospitalization. However, this meta-analysis was based on heterogeneously-designed studies.

 

~ Evidence from a multi-centric, suitably-designed randomized trial as well as trials to identify causes of mortality, and to assess whether mortality differs from dialysis dose are still needed.

 

 

https://www.dropbox.com/s/ex72edhz31jkhm9/Initiation%20time%20of%20renal%20replacement%20therapy%20on%20patients%20with%20acute%20kidney%20injury.pdf?dl=0

 

 

Comments

  1. Unknown5 November 2020 at 20:41

    There were gross limitations
    Statistically significant heterogeneity
    Significant diff in baseline BUN, Creat, APACHE II scores

    ReplyDelete

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